Topotecan prescribing information
WebFollowing administration of topotecan at doses of 0.5 to 1.5 mg/m 2 (0.3 to 1 times the recommended dose) administered as a 30-minute infusion, area under the curve (AUC) increases approximately proportional with dose. Distribution. Protein binding of topotecan is approximately 35%. Elimination. WebThe dose your child gets may be made up of 2 or more different strengths and colors of capsules. If your child throws up after taking this drug, do not repeat the dose. If the capsule is opened or broken, do not touch the contents. If the contents are touched or they get in the eyes, wash hands or eyes right away.
Topotecan prescribing information
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WebMar 22, 2024 · Alternatively, administer G-CSF 24 hours after the final dose of topotecan in the subsequent treatment course (i.e., beginning on day 4 of the 21-day treatment … WebSee full prescribing information for complete boxed warning. Doxorubicin hydrochloride can cause myocardial damage, including acute left ventricular failure. ... of HFS was 51% of patients in the doxorubicin hydrochloride liposome injection arm and 0.9% of patients in the topotecan arm, including 24% Grade 3 or 4 cases of HFS in doxorubicin ...
WebAfinitor/Afinitor Disperz prescribing information. Novartis. February 2024. 4. Alecensa prescribing information. Hoffmann-La Roche. September 2024. 5. Alunbrig prescribing information. Takeda Pharms USA. ... Hycamtin (topotecan) 0.25 mg capsule 21550080100120 M, N, O, or Y No Quantity Limit 1 mg capsule 21550080100140 M, N, O, … WebApr 28, 2024 · When topotecan is used in combination with cisplatin, the full prescribing information for cisplatin should be consulted. Prior to administration of the first course of topotecan, patients must have a baseline neutrophil count of ≥1.5 x 10 9 /l, a platelet count of ≥100 x 10 9 /l and a haemoglobin level of ≥9 g/dl (after transfusion if ...
Webtopotecan injection Quick Finder. Pfizer samples (for eligible HCPs) Requests for samples of prescription medications can be made by contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com. Report an adverse event or concern about the quality of a Pfizer product. WebIt was also clastogenic to mouse bone marrow. Topotecan did not cause mutations in bacterial cells. Topotecan given to female rats prior to mating at an intravenous dose of 1.4 mg/m 2 (about equal to the 1.5 mg/m 2 clinical dose based on BSA) caused superovulation possibly related to inhibition of follicular atresia. This dose given to pregnant ...
WebApr 5, 2024 · Common side effects of topotecan may include: low blood cell counts; trouble breathing, pneumonia. nausea, diarrhea, vomiting, stomach pain; loss of appetite; hair loss; or. feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
WebJun 9, 2024 · vomiting, stomach pain, loss of appetite, hair loss, weakness, and. tiredness. Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Hycamtin. … contribution to chemistry alfred nobelWebSep 7, 2024 · Topotecan is given intravenously (into a vein) or orally (by mouth). This teaching sheet focuses on the oral formulation. The dosage and schedule is determined by the person’s size, type of cancer, and regimen being used. When administered orally, the capsules should be taken at the same time every day with a glass of water. contribution to cell theory schwannWebFeb 14, 2024 · 7. Saltz L, Sirott M, Young C, et al. "Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor." J Natl Cancer Inst 85 (1993): 1499-507. 8. "Product Information. Hycamtin (topotecan)." contribution to 401k 2023Web16 HOW SUPPLIED/STORAGE AND HANDLING. Topotecan Injection is supplied in 4 mg/4 mL (1 mg/mL topotecan free base) single-dose vials. Each vial contains 4 mL of the sterile, … contribution to community resumeWebFeb 1, 2024 · WARNING: MYELOSUPPRESSION See full prescribing information for complete boxed warning. Topotecan can cause severe myelosuppression. Administer … contribution to 401kWeb16 HOW SUPPLIED/STORAGE AND HANDLING. Topotecan Injection is supplied in 4 mg/4 mL (1 mg/mL topotecan free base) single-dose vials. Each vial contains 4 mL of the sterile, clear, yellow to yellow-green solution. contribution to complying fundWebFULL PRESCRIBING INFORMATION . 1 . INDICATIONS AND USAGE . COSELA is indicated to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer (ES-SCLC). 2 DOSAGE AND … contribution to epf / approved scheme meaning