WebDetect, measure, and explore your target protein's identity and function using our products: peptides, recombinant proteins, antibodies, ELISA kits, NGS, and more. WebSur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, the roles of Sur8 in cellular physiologies are poorly understood. In this study, Sur8 was severely repressed in the course of neural progenitor cell (NPC) differentiation in the cerebral cortex of developing rat embryos.
The function of Shoc2: A scaffold and beyond - tandfonline.com
WebGet Rockland's Anti-SHOC2 (RABBIT) Antibody - 600-401-EJ4 for ELISA, IHC, WB. Reacts with Human. Order online now! WebIn addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR–TKIs in vivo. Furthermore, IHC showed the accumulation of cancer cells that … csx signals flashcards
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WebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway reactivation upon … Web17 Jun 2024 · Shoc2 partners and well-known ‘remodelers’, the AAA + ATPases PSMC5 and VCP/p97, make the HUWE1-modulated ubiquitination of Shoc2/RAF highly coordinated and precise. Analogous to its nonproteolytic function as an unfoldase/remodeler of AAA proteins independent of 20S (APIS) complexes [ [ 27 , 28 ] ], in the Shoc2 assembly, PSMC5 does … WebDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. Key Applications: Western Blotting; Immunohistochemistry; Application Notes: Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SHOC2 in human spleen tissue. csx signals