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Shoc2 ihc

WebDetect, measure, and explore your target protein's identity and function using our products: peptides, recombinant proteins, antibodies, ELISA kits, NGS, and more. WebSur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, the roles of Sur8 in cellular physiologies are poorly understood. In this study, Sur8 was severely repressed in the course of neural progenitor cell (NPC) differentiation in the cerebral cortex of developing rat embryos.

The function of Shoc2: A scaffold and beyond - tandfonline.com

WebGet Rockland's Anti-SHOC2 (RABBIT) Antibody - 600-401-EJ4 for ELISA, IHC, WB. Reacts with Human. Order online now! WebIn addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR–TKIs in vivo. Furthermore, IHC showed the accumulation of cancer cells that … csx signals flashcards https://milton-around-the-world.com

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WebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway reactivation upon … Web17 Jun 2024 · Shoc2 partners and well-known ‘remodelers’, the AAA + ATPases PSMC5 and VCP/p97, make the HUWE1-modulated ubiquitination of Shoc2/RAF highly coordinated and precise. Analogous to its nonproteolytic function as an unfoldase/remodeler of AAA proteins independent of 20S (APIS) complexes [ [ 27 , 28 ] ], in the Shoc2 assembly, PSMC5 does … WebDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. Key Applications: Western Blotting; Immunohistochemistry; Application Notes: Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SHOC2 in human spleen tissue. csx signals

Anti-SHOC2 Antibody ABS461

Category:RCSB PDB - 7TVF: Crystal structure of the SHOC2-MRAS-PP1CA …

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Shoc2 ihc

SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in

WebIHC; 1 /2. Western blot analysis of extracts from U-251 cells, using Sur-8 Antibody. DF12234 at 1/100 staining Rat liver tissue by IHC-P. Previous Next. 产品: Web21 Nov 2024 · Shoc2 activates ERK1/2 to promote tumor development through regulation of contact inhibition and cell polarization . Kaduwal et al. confirmed that Shoc2 regulates motility, invasion, and metastasis of cells through activation of the ERK and PI3K pathways. These results indicated that Shoc2 might play an important role in tumorigenesis and that ...

Shoc2 ihc

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Web20 Jun 2001 · Function. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS … WebA key phosphatase that mediates this dephosphorylation step is a heterotrimeric complex composed of MRAS, SHOC2, and protein phosphatase 1 (PP1) ().SHOC2 is a ubiquitously expressed protein composed almost exclusively of leucine-rich repeats (LRRs) that was originally identified in Caenorhabditis elegans as a positive modulator of the ERK pathway …

Web3 Feb 2024 · To confirm the clinical relevance of SHOC2 in patients with lung cancer with mutant EGFR, we collected biopsy specimens pre- and post-EGFR–TKI treatment and … WebYour search returned 219 Shoc2 Antibodies across 28 suppliers. Showing 28 of 28 suppliers (219 products total) ... Applications: WB, ELISA, ICC, IF, IHC-fr, IHC-p; Reactivity: Hu, Ms, …

WebSHOC2 Antibody, validated in WB, IHC-P, E (ASC10921), Abcepta. 18,000+ products cover the ten top research categories, including cancer, metabolism, cardiovascular ... WebLifeSpan BioSciences currently sells 26 antibodies , 4 peptides , 5 proteins specific for SHOC2.

WebFull gene name according to HGNC. SHOC2 leucine rich repeat scaffold protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to …

WebAnti-SHOC2 antibody (GTX130206) GeneTex Back Primary Antibodies Secondary Antibodies Antibody Panels ELISA Antibody Pairs & Kits Isotype Controls Proteins & Peptides Slides Lysates Serums & Plasmas Reagents Research Kits Research Tools Back Cancer Tumor Markers Neuroscience Cell Biology Metabolism Epigenetics Cardiovascular … csx slackWeb8 Jul 2024 · Selfors et al. (1998) showed that soc2 encodes a protein composed almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. They identified a putative human homolog, SHOC2, which is 54% identical to soc2. They showed that SHOC2 mRNA was expressed in all tissues assayed and that the SHOC2 protein is … ear nose and throat hospital edinburghWebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SHOC2 protein. … csx simple walking 3dWeb7.1 SHOC2 is required for MEKi-induced feedback relief RAF dimerization and ERK-activation 108 7.1.1 Introductory statement 108 7.1.2 SHOC2 deletion impairs rebound MEK phosphorylation by Selumetinib in H358 cells in both a dose and time-dependent manner. 108 7.1.3 SHOC2 is required for MEKi-induced feedback relief ERK-activation 110 ear nose and throat hospital birminghamear nose and throat hollidaysburg paWebSHOC2 is an activator of the RAS-ERK signal, whereas FBXW7 is a tumor suppressor that promotes SHOC2 ubiquitylation and degradation, it is not surprising to observe that two proteins counteract... ear nose and throat hickory ncWeb26 Oct 2024 · Furthermore, IHC showed the accumulation of cancer cells that express high levels of SHOC2 in lung cancer tissues obtained from patients with NSCLC who experienced acquired resistance to EGFR–TKIs. ear nose and throat high point nc