Progressive ankylosis protein
WebMutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and … WebNov 23, 2010 · Progressive ankylosis protein homolog (ANK), a transmembrane PPi transporter, and plasma-cell membrane glycoprotein 1 (PC-1) generate extracellular PPi Mutations in ANKH lead to familial CPPD
Progressive ankylosis protein
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WebAug 27, 2007 · Autosomal dominant craniometaphyseal dysplasia (designated AD-CMD in this review) is characterized by progressive diffuse hyperostosis of cranial bones evident clinically as wide nasal bridge, paranasal bossing, widely spaced eyes with an increase in bizygomatic width, and prominent mandible. WebKeywords Progressive osseous heteropalasia, GNAS gene, Novel mutation, Heterotopic ossification Background Progressive osseous heteroplasia (POH) is an extremely rare genetic disorder characterised by progressive forma-tion of heterotopic ossification in deep connective tis-sues and skeletal muscles [1].POH’s severity can range from subcutaneous …
WebFeb 21, 2024 · CIMPR, also known as IGF2R, does not only mediate binding of M6P-tagged acid-hydrolase for their lysosomal delivery, but plays also a role in internalizing insulin-like growth factor binding protein 2 (IGF2), a ligand critically controlling proper embryonic development (Ghosh et al., 2003a). WebPR:000004036 progressive ankylosis protein (term hierarchy) InterPro Domains. IPR009887 Progressive ankylosis. Molecular Reagents less. All nucleic 139. Genomic 1. cDNA 135. Primer pair 2. Other 1. Microarray probesets 3. Other Accession IDs less. MGD-MRK-1323, MGI:1098556, MGI:88023 References more. Summaries. All 90 ...
WebThe ANKH protein plays a role in the development and function of cells that build bones (osteoblasts) and cells that break down bone (osteoclasts). Osteoclasts are involved in … WebProtein-Protein Interactions (null) help help No protein-protein interactions found Nearest Tclin Targets help help Nearest Tclin calculations are only available for non-Tclin targets that have KEGG Pathway annotations. Pathways (undefined) help help No pathways found Viral Interactions (0) help help No viral interactions found
WebJun 17, 2024 · Craniometaphyseal dysplasia (CMD), a rare genetic bone disorder, is characterized by lifelong progressive thickening of craniofacial bones and metaphyseal flaring of long bones. The autosomal dominant form of CMD is caused by mutations in the progressive ankylosis gene ANKH (mouse ortholog Ank ), encoding a pyrophosphate …
WebDickkopf-related protein 1, an antagonist of Wnt/β-catenin signaling, has been reported to be either dysfunctional 88 or present at lower-than-normal levels in AS patients. 89 Serum levels of SOST are also lower in AS patients than healthy individuals. 90 Our recent work on ank/ank (progressive ankylosis) mice that have peripheral and spinal ... tapering fluoxetine to sertralineWebJul 1, 2003 · Progressive Ankylosis (Ank) Protein Is Expressed by Neurons and Ank Immunohistochemical Reactivity Is Increased by Limbic Seizures Author links open … tapering for competitionWebJun 30, 2016 · ANKH denotes human homologue of the protein product of the progressive ankylosis gene, ENPP1 ectonucleotide pyrophosphatase 1, eP i extracellular phosphate ion, ePP i extracellular PP i, IGF-1 ... tapering from methadoneWebApr 13, 2024 · Stapes ankylosis is characterized by hearing loss due to congenital or acquired stapes fixation. While otosclerosis is the most common progressive conductive hearing loss caused by stapes... tapering from lexapro to prozacWebJun 4, 2012 · Local levels of PPi are controlled by antagonistic functions of factors that decrease PPi and promote mineralization (tissue-nonspecific alkaline phosphatase, Alpl/TNAP), and those that increase local PPi and restrict mineralization (progressive ankylosis protein, ANK; ectonucleotide pyrophosphatase phosphodiesterase-1, NPP1). tapering from sertraline to mirtazapineWebOct 24, 2024 · The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans-Golgi network-to-endosome interface. Human … tapering for an ultramarathonWebJul 1, 2003 · Progressive Ankylosis (Ank) Protein Is Expressed by Neurons and Ank Immunohistochemical Reactivity Is Increased by Limbic Seizures Download PDF … tapering from suboxone