WebMar 7, 2013 · FAT1 is a member of a family of genes related to the Drosophila tumor suppressor fat and encodes for a transmembrane protocadherin protein that localizes to the cell membrane in epithelial tissues. Although FAT1 has been implicated in the regulation of cell–cell adhesion, its role in tumorigenesis is unclear. Morris and colleagues identified … WebStructure and function. Fat1 is located on chromosome 4q34–35 and consists of 27 exons. It is the first Fat family member to be identified and the most frequently studied Fat protein. Fat1 was cloned in 1995 from a human T-leukemia cell line and has since been shown to be closely related to human diseases. 1.
Recurrent somatic mutation of FAT1 in multiple human cancers ... - PubMed
WebFigure 1 Genomic analysis identified FAT1.(A) Flow chart of the protocol for genomic analysis of CTC and tissue DNA.(B) CTC and tissue genomic variants in patients with HCC.(C) Fluorescence images of captured CTCs.(D) The top five genes with the highest mutation frequency.(E) Combined analysis of CTC and tissue gene mutations.(F) … WebNov 1, 2024 · (A) Germline variants of uncertain significance coupled with somatic mutation on gene products of FAT1. Germline variants are colored in red, and somatic mutations are colored in blue. (B) Kaplan-Meier plot of patients presenting germline variants in FAT1 gene. The resulting p-values for the log-rank test are shown. small liberal arts colleges in california
Mutation overview page FAT1 - p.D4497N ( Substitution
WebNov 15, 2013 · FAT1 belongs to the FAT protocadherin family, a drosophila homologous gene involved in development processes. Recently, FAT1 gained large interest as it is mutated in various cancers. Besides the known function of cell-cell interaction and polarity, FAT1 loss of function mutations have been linked to dysregulation of the WNT pathway … WebMay 12, 2024 · FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers1–5. However, the role and the molecular mechanisms by which … WebFAT1 mutations and downregulation defined nodal involvement, lymphovascular permeation and tumor recurrence. In addition, FAT1 mutations and downregulation are … high-quality colorimeter