2024 Cisplatin vs carboplatin ototoxicity

Cisplatin vs carboplatin ototoxicity

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August undefined, 2024

WebFinal results indicate that the investigational chemotherapeutic analogs CBDCA (JM-8) and CHIP (JM-9) do not produce the ototoxicity and nephrotoxicity characteristic of cisplatin. Furthermore, these findings demonstrate 195mpt localization in the vestibular labyrinth and confirm previous platinum distribution studies in the organ of Corti and ... Web18/40 (45%) evidence of ototoxicity at audiometry. To date we have seen no neuro- or ototoxicity with carboplatin and 1/40 (2.5%) have developed WHO grade I renal toxicity. Myelo- ... Key words: Ovarian cancer; cisplatin, carboplatin, toxicity, efficacy, randomized study. Cisplatin is the most active drug in ovarian cancer ...

Mechanisms of Cisplatin-Induced Ototoxicity and …

WebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative risk 0.58 (95% CI: 0.40, 0.83). WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This … flightmike youtube

Serum platinum levels and cisplatin induced ototoxicity among …

WebMar 25, 2024 · The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity guidelines. Case series including retrospective medical records review of patients (age > 18) treated … WebJan 1, 2024 · Regarding the frequency of ototoxicity of antineoplastic drugs and the dose required to trigger these effects, an important heterogeneity was observed. The frequency of ototoxicity caused by cisplatin ranged from 45% to 83.3% and, when used in combination with carboplatin, ranged from 16.6% to 75%. WebOtotoxicity of cisplatin as a single therapeutic agent is well documented. Less is known, however, about its interaction with other drugs and/or cranial irradiation. For example, ifosfamide, given as a single agent, is not known to be ototoxic but appears to potentiate the ototoxicity of cisplatin ( McHaney et al., 1992 ). chemist warehouse ciprofloxacin

Platinum-induced ototoxicity: a review of prevailing ototoxicity ...

Insight into the current practice of ototoxicity monitoring during ...

http://mdedge.ma1.medscape.com/obgyn/article/97636/gynecologic-cancer/paclitaxel-carboplatin-should-be-standard-option-advanced WebOct 8, 2010 · Carboplatin, a therapeutic alternative to cisplatin, has been shown to be less ototoxic, with reported toxicity rates of 0–38% [ 4, 10 – 12, 18, 19 ]. Carboplatin is also … flight milanWebCis-diamminedichloroplatinum (cisplatin), a divalent platinum compound and cell-cycle nonspecific chemotherapeutic agent, produces a permanent high-frequency … flight milan to athens

"WebJul 3, 2024 · Cisplatin is a widely used chemotherapeutic agent with a high degree of ototoxicity and an average incidence of over 60% ( Karasawa and Steyger, 2015 ). Ototoxicity depends on several factors, including patient age, cumulative dose of cisplatin, and genetic susceptibility ( Landier, 2016; Lanvers-Kaminsky and Ciarimboli, 2024 ). " - Cisplatin vs carboplatin ototoxicity

Cisplatin vs carboplatin ototoxicity

WebDec 7, 2024 · Background Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of treatment. In this study, we compared the efficacy and safety between the cisplatin plus etoposide (EP) and carboplatin plus etoposide (EC) regimens. Methods … WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. …

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WebSep 21, 2016 · Cisplatin is the most ototoxic drug known, and a mean ototoxicity incidence of 33% has been reported when patients received a single dose of 50 mg/m 2 … WebAlthough cisplatin has demonstrated its superiority over carboplatin for treatment of lung cancers and germ-cell tumors, the tolerance of carboplatin is better than that of …

WebMar 3, 2015 · Key clinical point: Paclitaxel plus carboplatin is noninferior to paclitaxel plus cisplatin for metastatic or recurrent cervical cancer. Major finding: The carboplatin regimen, with a median overall survival of 17.5 months, proved to be noninferior to the cisplatin regimen, which had a median OS of WebEfficacy and safety of a cisplatin and paclitaxel (TP) induction regimen followed by chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC)

WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin crosses into the cochlea, which often results in permanent sensorineural cisplatin-induced hearing loss (CIHL). WebSep 15, 2024 · Carboplatin (kar" boe pla' tin) is a cisplatin analog with a carboxy-cyclobutane moiety instead of the chloride atoms which makes it more stable and perhaps less toxic than cisplatin. Carboplatin and cisplatin act as alkylating agents causing cross linking between and within DNA strands, leading to inhibition of DNA, RNA and protein …

WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity.

WebThe dose-limiting side effect for cisplatin is nephrotoxicity, for carboplatin it is myelosuppression, and for oxaliplatin it is neurotoxicity. Other common side effects … flight milan to amsterdamWebCisplatin is used in the treatment of several childhood malignancies. Improvement in long -term survival has made the monitoring of long-term side effects more important. Nephrotoxicity and high frequency hearing loss are the most notable adverse effects of cisplatin in children. Brock et. al (1991) chemist warehouse cinnamonWebAug 19, 2007 · Pooling the results of all of these cis vs. carbo studies together, the response rate with cisplatin combinations was higher (30% vs. 24%), and the overall survival … flight milan to londonWebFeb 26, 2024 · The cisplatin ototoxicity occurs between 23% and 50% in adults and up to 60% in children [4,6]. However, some studies have reported elevated hearing thresholds in up to 100% of cisplatin-treated cancer patients [7,8], while it is estimated to be 63% with aminoglycosides and 6-7% with furosemide [9]. chemist warehouse cioWebThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. chemist warehouse city crossWebIbero-American Expert Consensus on Squamous Cell Carcinoma of the Head and Neck Treatment in Patients Unable to Receive Cisplatin Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. chemist warehouse church street parramattaWebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 ... This is a review of cisplatin-induced ototoxicity and strategies to minimize the negative impact on QoL and outcome. flight mileage and time calculator